Folliculin interacting protein 1
WebFolliculin (FLCN) is a tumor suppressor gene responsible for the inherited Birt-Hogg-Dubé (BHD) syndrome, which affects kidneys, skin and lungs. … WebDec 24, 2024 · FNIP1 folliculin interacting protein 1. Gene ID: 96459, updated on 24-Dec-2024. Gene type: protein coding. Also known as: IMD93. See all available tests in GTR …
Folliculin interacting protein 1
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WebLOC127985354 folliculin-interacting protein 1 [ (silver crucian carp)] Gene ID: 127985354, updated on 2-Mar-2024. Summary Other designations. folliculin … WebMar 5, 2024 · FLCN and its binding partners, FNIP1/2, are Rag-interacting proteins with GAP activity for RagC/D, but not RagA/B. FLCN localizes to motile and non-motile cilia, centrosomes and the mitotic spindle. Alteration of FLCN levels can cause changes to the onset of ciliogenesis.
WebNext-day shipping cDNA ORF clones derived from FNIP2 folliculin interacting protein 2 available at GenScript, starting from $99.00. WebBirt-Hogg-Dubé (BHD) syndrome is an autosomal dominant disorder characterized by cutaneous fibrofolliculomas, pulmonary cysts, and kidney malignancies. Affected individuals carry germ line mutations
WebJul 1, 2007 · FNIP1 is a novel protein with no domains to suggest function. By coimmunoprecipitation studies FNIP1 was also found to interact with the heterotrimer, … WebMar 16, 2015 · Folliculin (FLCN)-interacting proteins 1 and 2 (FNIP1, FNIP2) are homologous binding partners of FLCN, a tumor suppressor for kidney cancer. …
Folliculin (FLCN) functions as a binding partner and uncompetitive inhibitor of Lactate Dehydrogenase-A (LDHA). A flexible loop within the amino-terminus of FLCN controls movement of the LDHA active site loop, tightly regulating its enzyme activity and, consequently, metabolic homeostasis in normal cells. See more The tumor suppressor gene FLCN encodes the protein folliculin, also known as Birt–Hogg–Dubé syndrome protein, which functions as an inhibitor of Lactate Dehydrogenase-A and a regulator of the Warburg effect. … See more Structure The FLCN gene consists of 14 exons. Location Cytogenetic location: The FLCN gene is located on the short (p) arm of chromosome 17 at position 11.2. (17p11.2). See more • FLCN+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • The BHD Foundation Archived 2024-06-11 at the Wayback Machine supports research into BHD syndrome and maintains the world's first website … See more Interactions FLCN has been shown to interact through its C-terminus with two new co-chaperones folliculin interacting protein 1 (FNIP1) and folliculin interacting … See more • Schmidt LS, Linehan WM (October 2015). "Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome". Nature Reviews. Urology. 12 (10): 558–69. doi: • Tee AR, Pause A … See more
WebNov 30, 2010 · Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or … locofrank youtubeWebMar 9, 2024 · folliculin-interacting protein 1. GeneRIFs: Gene References Into Functions. Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human … indigo thirty sweatpantsWebNov 13, 2014 · Tti1, a putative novel mTOR-binding protein, positively regulates mTOR activity and interacts with Tel2, a common partner in the assembly of the mTOR complex, to maintain its activity [ 30, 31 ]. Raptor, mLTS8, Tti1, and Tel2 are essential for activating mTORC1 signaling by growth factors and amino acids. indigo thread company clothing for womenWebRecent studies using murine models for FLCN, a protein encoded by the FLCN gene, and its two binding partners, folliculin-interacting protein 1 (FNIP1) and folliculin-interacting protein 2 (FNIP2), have uncovered important roles for FLCN, FNIP1 and FNIP2 in cell metabolism, which include AMP-activated protein kinase-mediated energy sensing, … locofrank oneWebFolliculin is a novel 64-kDa protein without characteristic domains to suggest function (Nickerson et al., 2002). We recently identified FNIP1, a novel folliculin-interacting … indigo throw blanketWebMar 21, 2024 · FNIP1 (Folliculin Interacting Protein 1) is a Protein Coding gene. Diseases associated with FNIP1 include Immunodeficiency 93 And Hypertrophic Cardiomyopathy … loco foods catalogWebFolliculin (FLCN) is a tumor-suppressor protein mutated in the Birt–Hogg–Dubé (BHD) syndrome, which associates with two paralogous proteins, folliculin-interacting protein (FNIP)1 and FNIP2, forming a complex that interacts with … indigo thread on shop hq