WebPERK and eIF2a were silenced using siRNA transfection to analyze the regulation of radioresistance by PERK-eIF2a through the NF-jB signaling pathway in oropharyngeal carci-noma cells. In addition, the pathways and mechanisms under-lying this function were investigated to identify new therapeutic targets to increase the radiotherapy efficacy in WebNov 21, 2024 · It is discovered that eIF2A‐KO mice have reduced life span and that eif2A plays an important role in maintenance of lipid homeostasis, the control of glucose tolerance, insulin resistance and also reduces the abundance of B lymphocytes and dendritic cells in the thymic medulla of mice. 4 PDF View 3 excerpts, references methods
mRNA-specific tRNAi carrier eIF2A plays a pivotal role in cell ...
WebMar 17, 2024 · This review summarizes our current understanding of the structure and function of a single subunit eukaryotic initiation factor 2A (eIF2A), that was initially believed to serve as the functional homologue … WebJan 5, 2024 · Eif2a/Eif4e double mutants showed a severe growth defect, disorganized actin cytoskeleton, and elevated actin levels, suggesting that these factors have a role in cell morphology. Expression of Eif2a downregulated Ure2 internal ribosome entry site (IRES) activity in yeast cells. barbara faludi yoga principianti
eIF2A‐knockout mice reveal decreased life span and metabolic …
WebJan 26, 2013 · Attenuation of mRNA translation through eIF2α phosphorylation functions to inhibit viral replication by blocking synthesis of viral proteins and by executing apoptosis; therefore, it is no surprise that … eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM] It may be important for translation initiation mediated by the HCV IRES under stress conditions, but this result has been debated. WebApr 20, 2024 · Overall, our findings show that proper cell type-specific regulation of PERK-eIF2 signaling in DA neurons is required for normal motor and cognitive function, and that the UPR plays a critical ... barbara fanelli warminster pa