WebJan 1, 2024 · The adducts occur through a coordinated covalent bonding between the platinum atom of cisplatin and two nitrogen atoms (N7s) of two purine bases (mostly adjacent guanine–guanine) [6]. As a result, the drug can also cause collateral cell damage because the adducts form equally well in cancerous and normal cells. WebJul 6, 2024 · A synthetic cluster that binds and reduces nitrogen molecules casts light on the mechanism of fixation. A model of the active site of nitrogenase enzymes.
Interactions of the Platinum(II) Complexes with Nitrogen- and …
WebCisplatin is an alkylating agent that prevents DNA replication in cells. It consists of two ammonia ligands and two chloride ligands bonded to a central platinum ion. Cisplatin works by bonding to nitrogen atoms in the base guanine using a ligand substitution reaction. This damages the cell's DNA, prevents DNA replication and triggers cellular ... WebJun 12, 1998 · During the later stages of reactions of cisplatin with albumin, release of NH3 occurs due to the strong trans influence of Met sulfur, which weakens the Pt-NH3 bonds, and protein cross-linking is observed. The consequences of these findings for the biological activity of cisplatin-albumin complexes are discussed. Publication types eric sprunk net worth
Cisplatin 12. Modes of Action of Cisplatin - Chemistry LibreTexts
WebApr 10, 2024 · Pd 3 Spd 2 and Pt 3 Spd 2 can bind with high affinity to the nitrogen atoms of the DNA bases, mainly to the purines (the adduct with guanine being favored by intramolecular H-bonds). WebQuestion 47 of 60 Option Cisplatin molecules bind to nitrogen atoms at which DNA base? A. Cytosine B. Guanine C. Adenine D. Uracil Flag for Review POVIDES < Back to … http://www.chm.bris.ac.uk/motm/cisplatin/htmlonly/cpmechanism.htm find tables with column name postgresql